Lipid peroxidation in the brain and liver of rats during acute stress and melatonin treatment |
| |
| Authors: | Email author" target="_blank">S?S?PertsovEmail author G?V?Pirogova |
| |
| Institution: | (1) Department for Physiology of Emotions and Emotional Stress, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Science, Moscow |
| |
| Abstract: | We studied the effects of acute stress and exogenous melatonin in various doses on the intensity of lipid peroxidation in
emotiogenic structures of the brain and liver of rats with different activity in the open field. Stress had no effect on the
content of malonic dialdehyde in the hypothalamus, sensorimotor cortex, and liver of active and passive rats receiving physiological
saline. The influence of melatonin on malonic dialdehyde content depended on the dose of this substance. The amount of malonic
dialdehyde in brain structures (active and passive rats) and liver (active rats) increased after administration of exogenous
melatonin in doses of 0.5 and 2 mg/kg, but decreased after treatment with the hormone in a dose of 1 mg/kg. Melatonin in various
doses decreased malonic dialdehyde content in the liver of passive rats. The effects of melatonin are partly related to modulation
of lipid peroxidation in central and peripheral tissues of the organism.
Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 7, pp. 19–23, July, 2004 |
| |
| Keywords: | acute stress lipid peroxidation melatonin brain liver |
| 本文献已被 SpringerLink 等数据库收录！ |
|
