| 毛细管气相色谱法测定加替沙星中二甲基亚砜残留量 |
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| 引用本文： | 吴丽仙.毛细管气相色谱法测定加替沙星中二甲基亚砜残留量[J].中国药业,2008,17(10):44-45. |
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| 作者姓名： | 吴丽仙 |
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| 作者单位： | 浙江瑞新制药有限公司,浙江,丽水,310004 |
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| 摘 要： | 目的用毛细管气相色谱方法测定加替沙星中的残留溶剂二甲基亚砜。方法色谱柱为DB-624（6％氰丙基苯基-94％二甲基聚硅氧烷固定液）石英毛细管柱（30.0m×0.53mm，3.0μm），载气为氮气，进样口温度为230℃，FID检测器温度为250℃，柱温为140℃，直接进样，分流比为10：1，溶剂为二甲基甲酰胺。结果被测物均能得到很好分离，峰面积与质量浓度呈良好的线性关系，精密度和回收率良好。结论该法可用于加替沙星原料药中残留溶剂二甲基亚砜的检测。
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| 关 键 词： | 加替沙星 残留溶剂 二甲基亚砜 毛细管气相色谱 |
| 文章编号： | 1006-4931(2008)10-0044-02 |
| 修稿时间： | 2007年9月19日 |
Determination of Dimethyl Sulfoxide in Gatifloxacin by CGC |
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| Wu Lixian.Determination of Dimethyl Sulfoxide in Gatifloxacin by CGC[J].China Pharmaceuticals,2008,17(10):44-45. |
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| Authors: | Wu Lixian |
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| Institution: | Wu Lixian (Zhejiang Ruxin Pharmaceutical Co. Ltd., Lishui, Zhejiang, China 310004) |
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| Abstract: | Objective To establish a method of capillary gas chromatography（CGC）for the determination of dimethyl sulfoxide（residual solvent） in gatifloxacin. Methods Dimethyl sulfoxide in gatifloxacin was separated by DB-624 capillary column（30.0m×0.53mm,3.0μm） with FID detector. The carried gas was nitrogen. The injector temperature and the detector temperature was controlled at 230℃ and 250℃, respectively. The column temperature was maintained at 140℃. The sample was dissolved in dimethylformamide. The direct injection was used, the splitting - ratio was 10 ： 1. Results The measured solvent were separated completely. The calibration curve of dimethyl sulfoxide showed a good linear relationship with good precision and accuracy. Conclusion The established method is accurate and reliable. It can be used for the determination of dimethyl sulfoxide in gatifloxacin. |
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| Keywords: | gatifloxacin residual solvent dimethyl sulfoxide capillary gas chromatography （CGC） |
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