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Revisiting the relationships of 2D:4D with androgen receptor (AR) gene and current testosterone levels: Replication study and meta-analyses |
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| Authors: | Kejin zhang Xing Yang Mengfei zhang Chunlan Wang Pengpeng Fang Mengying Xue Jing Zhao Xiaocai Gao Ruliang Pan Pingyuan Gong |
| Affiliation: | 1. Shaanxi Key Laboratory for Animal Conservation, Northwest University, Xi'an, China College of Life Science, Northwest University, Xi'an, China;2. College of Life Science, Northwest University, Xi'an, China;3. Institute of Population and Health, Northwest University, Xi'an, China;4. Shaanxi Key Laboratory for Animal Conservation, Northwest University, Xi'an, China School of Human Sciences, Centre for Evolutionary Biology, The University of Western Australia, Perth, WA, Australia School of Biological Sciences, The University of Western Australia, Perth, WA, Australia;5. Shaanxi Key Laboratory for Animal Conservation, Northwest University, Xi'an, China |
| Abstract: | The relationships of digit ratio (2D:4D) with the length of AR (CAG)n, and testosterone levels from saliva and blood have been extensively debated over the years. This research including three studies further clarifies such controversies. To do so, we re-examined the relationships between the length of AR (CAG)n, 2D:4D, and current testosterone levels, through replication study and meta-analysis for each study. The results indicate: (a) the length of AR (CAG)n is not significantly associated with 2D:4D; (b) current testosterone levels are not significantly associated with the ratio; and (c) the length is not significantly associated with testosterone levels. Thus, AR (CAG)n and current testosterone levels are not significantly related to 2D:4D at individual level. |
| Keywords: | androgen receptor meta-analysis 2D:4D replication study testosterone |