Ammonia predicts poor outcomes in patients with hepatitis B virus-related acute-on-chronic liver failure |
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| Authors: | JinFei Zhang XiaoLu Liu Bo Ye Hui Chen |
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| Institution: | 1. Department of Clinical Laboratory, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou, China;2. Department of Clinical Laboratory, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China |
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| Abstract: | BackgroundHepatic encephalopathy (HE) is a common feature of acute liver failure and has been reported to be associated with poor outcomes. Ammonia is thought to be central to the pathogenesis of HE, but its role in hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF) is unclear. The present study aimed to assess the prognostic role of ammonia level for patients with HBV‐ACLF.MethodsWe retrospectively recruited 127 patients diagnosed with HBV‐ACLF for the present study.ResultsAmmonia levels at the time of admission were higher among non‐surviving participants than in survivors. Increased ammonia level was found to be associated with severe liver disease and was identified as an independent predictor for mortality in patients with HBV‐ACLF.ConclusionsOur results suggest that high ammonia level at admission is an independent factor for predicting short‐term mortality in patients with HBV‐ACLF. Therefore, ammonia levels may represent a therapeutic target for this condition. |
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| Keywords: | acute-on-chronic liver failure ammonia Hepatitis B virus mortality |
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