应用MEBO治疗小面积骨外露创面13例报告

目的：观察不植皮用MEBO治疗范围小于5cm^2的骨外露创面的效果，探讨裸露骨皮质钻孔后培育肉芽，上皮组织生长的机制。方法：对范围小于5cm^2的骨外露创面经骨皮质钻孔后直接外用MEBO换药、每日3～4次直到创面愈合。并对不同时期的新鲜肉芽，上皮组织等分别活检切片，观察探讨其上皮组织生长的机理。结果：13例裸骨创面均有良好的肉芽生长，最终为上皮组织覆盖。创面修复的时间与部位血供有明显差异、与用药方法密切相关。结论：MEBO可促进骨质外露创面的肉芽组织生长，对范围小于5cm^2的裸骨创面，经骨皮质钻孔及MEBO规范治疗后自行上皮组织修复，血供丰富部位的创面愈合时间明显提前．该方法简单实用，是一种理想的治疗措施。

Thirteen cases of small area bone exposure treated with MEBO

Objective: To observe the efficacy of MEBO in treating small area bone exposure and to investigate the mechanism of the granulation and epithelial tissue growth in exposed cortex of bone. Method: Small area (less than 5 cm2) bone exposure wounds were treated with MEBO after drilling of the cortex. MEBO was applied 3 to 4 times a day until the wounds healed. Fresh granulation and epithelial tissue biopsy specimens were examined at different stages, to explore the condition and the mechanism of the their growth. Result: Thirteen patients all had good granulation in exposed bone wounds and finally covered by epithelial tissue. The wound repairing time was different with different blood supply and was closely related to the method of the application of the drug. Conclusion: MEBO can promote granulation in exposed bone wounds, with an area less than 5 cm2. After drilling of the bone cortex, MEBO can promote spontaneous repair of epithelial tissue. With adequate blood supply, the wound healing time can be shortened. This method is easy and practical.