我院2009-2012年1735株鲍曼不动杆菌临床分布及耐药性分析

目的:调查我院鲍曼不动杆菌的临床分布及其对抗菌药物的耐药情况,为临床合理用药提供依据。方法:将2009-2012年我院临床各种来源的1 735株鲍曼不动杆菌采用最低抑菌浓度(MIC)法进行药敏试验,并对结果进行统计分析。结果:标本主要来自于痰液,1 579株,占91.0%;临床分布以呼吸科(包括呼吸重症监护病房)最多,827株,占47.7%,其次为重症监护病房(包括冠心病监护病房),502株,占28.9%。该菌对临床常用抗菌药物高度耐药和多重耐药,且耐药率逐年增高,对亚胺培南和美罗培南的耐药率均高于60%。结论:鲍曼不动杆菌耐药情况相对严重,耐药谱不断发生变化,临床应加强监测,合理使用抗菌药物。

Analysis of Clinical Distribution and Drug Resistance of 1 735 Strains of Acinetobacter baumannii in Our Hospital during 2009--2012

OBJECTIVE： To investigate clinical distribution of Acinetobacter baumannii and its resistance against antibiotics, and to provide foundation for rational use of drugs in the clinic. METHODS： 1 735 strains ofA. baumannii isolated from different clinical departments during 2009 to 2012 were tested for their drug sensitivity with MIC method, and the results were analyzed sta tistically. RESULTS： A. baumannii were mainly from sputum samples （91.0%, 1 579 strains）, mainly from respiratory departments including ILICU （47.7%, 827 strains）, followed by ICU including CCU accounting for 28.9% （502 strains）. Their multidrug and high resistance rate against commonly used antibiotics become higher year by year. The resistance rate of imipenem and meropenem was higher than 60%. CONCLUSIONS： Drug resistance of A. baumannii in the hospital becomes relatively serious and changing continuously. It is necessary to strengthen the clinical monitoring and the rational use of antibiotics.