空气氯乙烯污染与人群免疫效应

Immunological Effects of Air Vinyl Chloride Pollution to Population

A exposure-control study of 10 children (aged 10 to 12) and 12 workers exposed to vinyl chloride(VC)are reported by using the informed erythrocyte rosette forming test(E- RFT), neutrophilic granulocyte phagocytosis (NGP) test and phytohemagglutinin (PHA) skin test as immunological indexes in order to observe the effects of air VC pollution to the immune function of the population. The re- sults show that all cellular immunological in- dexes in workers exposed to VC concentration more than 30mg/m~3 are significantly lower than control (p<0.01) and the cellular toxici- ty are shown. The E-RFT in children ex- posed to VC concentration no less than 0. 18mg/m~3 is significantly lower than that of control (p<0. 01) and the Tecell function is inhibited. The degree of E-RFT decreased a- gree with that of VC contact amount in- creased. The E-RFT of the group exposed to VC concentration less than 0. 08mg/m~3 are similar with upper part of normal ERFT. The study shows that the air VC concentration no more than 0.08mg/m~3 can be recommended as noeffect level and E-RFT is a sensitive index of cellular immune effect on population and the cellular immune index can be used as one of subjects for monitoring VC occupationally exposed population.