Automated auditory brainstem response in preterm newborns with histological chorioamnionitis |
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| Authors: | Adriana L. Smit Jasper V. Been Luc J. I. Zimmermann Rene F. Kornelisse Peter Andriessen Sizzle F. Vanterpool |
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| Affiliation: | 1. Department of Otorhinolaryngology/Head and Neck Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands,;2. School for Mental Health and Neuroscience, University of Maastricht, Maastricht, The Netherlands,;3. Department of Pediatrics, Maastricht University Medical Centre, Maastricht, The Netherlands,;4. School for Public Health and Primary Care (CAPHRI), University of Maastricht, Maastricht, The Netherlands,;5. School for Mental Health and Neuroscience, University of Maastricht, Maastricht, The Netherlands,;6. School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands,;7. Department of Pediatrics, Erasmus University Medical Centre-Sophia Children’s Hospital, Rotterdam, The Netherlands,;8. Department of Pediatrics, Máxima Medical Centre Veldhoven, Veldhoven, The Netherlands,;9. Faculty of Health, Medicine and Life Science, Maastricht University, The Netherlands, and;10. Department of Pediatrics, Maastricht University Medical Centre, Maastricht, The Netherlands, |
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| Abstract: | Objective: We investigated whether histological chorioamnionitis is associated with an adverse neonatal hearing outcome.Methods: Two cohorts of very preterm newborns (n?=?548, gestational age ≤ 32.0 weeks) were linked to placental histology and automated auditory brainstem response (AABR) outcome.Results: In multivariable analyses, an abnormal AABR was not predicted by the presence of histological chorioamnionitis, either with or without fetal involvement (OR 1.4, 95% CI 0.5 – 3.8, p?=?0.54 and OR 1.1, 95% CI 0.4–3.0, p?=?0.79, respectively). Significant predictors of abnormal AABR included, e.g. birth weight (per kg increase: OR 0.2, 95% CI 0.0–0.6, p?=?0.006), umbilical cord artery pH (per 0.1 increase: OR 0.7, 95% CI 0.5–0.9, p?=?0.005) and mechanical ventilation (OR 3.7, 95% CI 1.2–11.6, p?=?0.03).Conclusions: Histological chorioamnionitis was not associated with an adverse neonatal hearing outcome in two cohorts of very preterm newborns. Indicators of a complicated neonatal clinical course were the most important predictors of an abnormal hearing screening. |
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| Keywords: | Automated auditory brainstem response chorioamnionitis hearing screening preterm infants |
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