Women with endometriosis at first pregnancy have an increased risk of adverse obstetric outcome |
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Authors: | Nathalie Conti Gabriele Cevenini Silvia Vannuccini Cinzia Orlandini Herbert Valensise Maria Teresa Gervasi |
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Institution: | 1. Department of Molecular and Developmental Medicine,;2. Department of Medical Biotechnology, University of Siena, Siena, Italy,;3. Department of Biomedicine, Obstetrics and Gynecology, Tor Vergata University, Rome, Italy,;4. Obstetrics and Gynecology Unit, Department of Women and Children Health, AOP, Padova, Italy, |
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Abstract: | Objective: To evaluate pregnancy, delivery and neonatal outcome in singleton primiparous versus multiparous women with/without endometriosis.Methods: Multicentric, observational and cohort study on a group of Caucasian pregnant women (n?=?2239) interviewed during their hospitalization for delivery in five Italian Gynecologic and Obstetric Units (Siena, Rome, Padua, Varese and Florence).Results: Primiparous women with endometriosis (n?=?219) showed significantly higher risk of small for gestational age fetuses (OR: 2.72, 95% CI 1.46–5.06), gestational diabetes (OR: 2.13, 95% CI 1.32–3.44), preterm premature rupture of membranes (OR: 2.93, 95% CI 1.24–6.87) and preterm birth (OR: 2.24, 95% CI 1.46–3.44), and were hospitalized for a longer period of time (p?0.0001) comparing with control group (n?=?1331). Multiparous women with endometriosis (n?=?97) delivered significantly more often small for gestational age fetuses (OR: 2.93, 95% CI 1.28–6.67) than control group (n?=?592). Newborns of primiparous women with endometriosis needed more frequently intensive care (p?=?0.05) and were hospitalized for a longer period of time (p?0.0001).Conclusions: Women with endometriosis at first pregnancy have an increased risk of impaired obstetric outcome, while a reduced number of complications occur in the successive gestation. Therefore, it is worthy for obstetricians to increase the surveillance in nulliparous women with endometriosis during pregnancy. |
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Keywords: | Endometriosis gestational diabetes neonatal complications pPROM pregnancy outcome preterm birth small for gestational age |
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