Association of LOC387715/ARMS2 (rs10490924) Gene Polymorphism with Age-Related Macular Degeneration in the Brazilian Population |
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| Authors: | Fabio Endo Hirata José Paulo Cabral de Vasconcellos Flávio MacCord Medina Priscila Hae Hyun Rim Enzo Augusto Medeiros Fulco |
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| Affiliation: | Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas – UNICAMP, Campinas, SP, Brazil and |
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| Abstract: | Background: An association between LOC387715/ARMS2 (rs10490924) gene polymorphism and AMD has been reported. The aim of this study was to evaluate whether this polymorphism is associated with AMD in a Brazilian cohort.Materials and Methods: In total, 126 unrelated AMD patients (mean age 74.17?±?7.64) were compared with 86 healthy controls (mean age 71.82?±?7.12). Study subjects were classified according to the International ARM Epidemiological Study Group definition for early and late-stage AMD. LOC387715/ARMS2 rs10490924 polymorphism was evaluated through polymerase chain reaction and direct sequencing.Results: The T allele frequency was significantly higher in AMD patients than in controls (39.6% compared to 20.3%). The odds ratio (OR) for AMD was 2.05 (95% CI 1.13–3.71) for heterozygotes (TG) and 8.32 (95% CI 2.30–45.99) for homozygotes (TT).Conclusions: These results suggest that there is a contribution of the rs10490924 SNP of the LOC387715/ARMS2 gene to AMD susceptibility in this sample of the Brazilian population. |
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| Keywords: | AMD LOC387715/ARMS2 macular degeneration polymorphism rs10490924 |
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