Improvement in skin wrinkles using a preparation containing human growth factors and hyaluronic acid serum |
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| Authors: | Do Hyun Lee In Young Oh Kyo Tan Koo Jang Mi Suk Sang Wook Jung Jin Oh Park |
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| Institution: | 1. Nutrex Technology R&2. D Center, Seoul, South Korea;3. Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea;4. P&5. K Skin Research Center, Seoul, South Korea;6. Daebong LS, Incheon, South Korea |
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| Abstract: | Background: Skin aging is accompanied by wrinkle formation. At some sites, such as the periorbital skin, this is a relatively early phenomenon. Objective: We evaluated the anti-wrinkle effect of a preparation containing human growth factor and hyaluronic acid serum on periorbital wrinkles (crow's feet). Materials and methods: In total, 23 Korean women (age range: 39–59 years), who were not pregnant, nursing, or undergoing any concurrent therapy, were enrolled in this study. All the patients completed an 8-week trial of twice-daily application of human growth factor and hyaluronic acid serum on the entire face. Efficacy was based on a global photodamage score, photographs, and image analysis using replicas and visiometer analysis every 4 weeks. The standard wrinkle and roughness parameters used in assessing skin by visiometer were calculated and statistically analyzed. Results: Periorbital wrinkles were significantly improved after treatment, with improvements noted both by physician's assessment and visiometer analysis. Conclusion: Topical application of human growth factor and hyaluronic acid was beneficial in reducing periorbital wrinkles. |
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| Keywords: | human growth factor hyaluronic acid wrinkle |
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