Comparison of the effects of carboxytherapy and radiofrequency on skin rejuvenation

Background: Carboxytherapy (CA) refers to the cutaneous and subcutaneous administration of CO₂ for therapeutic purposes. Radiofrequency (RF) is a method that uses electric current for heating layers of the skin. Both techniques are indicated for the treatment of skin laxity. Objective: The aim of this study was to compare the effects of CA and RF on human skin. Methods: After eight patients underwent abdominoplasty, each of them received a single treatment of CA and a single treatment of RF on the right and left infra-umbilical regions, respectively. In the infra-umbilical region, CA was performed on the right and RF was performed on the left side. Untreated skin was used as a control. The sample collection period lasted 120 days. CA was administered at a velocity of 40 mL/min, and the total quantity of CO₂ infused was approximately 20 mL. RF was carried out at a temperature higher than 40°C on the epidermis for 5 min. Results: CA and RF led to collagen remodeling; however, this result was more evident and lasted longer with RF. With CA an increase in elastic fibers was observed, whereas with RF no alteration was observed. Conclusion: Our results suggest that RF is more efficient than CA in stimulating collagen synthesis.