| 丙型肝炎病毒感染与糖尿病 |
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| 引用本文： | 毛日成,尹有宽. 丙型肝炎病毒感染与糖尿病[J]. 国际流行病学传染病学杂志, 2006, 33(4): 255-257 |
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| 作者姓名： | 毛日成 尹有宽 |
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| 作者单位： | 200040,上海,复旦大学附属华山医院传染科;200040,上海,复旦大学附属华山医院传染科 |
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| 摘 要： | 近年来,有很多流行病学调查证实了HCV感染与糖尿病的关联,这种关联在年龄大、体重超标的患者身上表现更为明显。HCV编码的蛋白,能干扰胰岛素的信号转导,这就解释了在发生肝纤维化之前,HCV感染者出现胰岛素抵抗的原因,而胰岛素抵抗也促进了肝纤维化的进程。
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| 关 键 词： | 丙型肝炎病毒 糖尿病 流行病学 |
| 收稿时间： | 2005-11-28 |
| 修稿时间： | 2005-11-28 |
The link between hepatitis C virus infection and diabetes mellitus |
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| MAO Ri-cheng,YIN You-kuan. The link between hepatitis C virus infection and diabetes mellitus[J]. International Journal of Epidemiology and Infectious Disease, 2006, 33(4): 255-257 |
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| Authors: | MAO Ri-cheng YIN You-kuan |
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| Affiliation: | Department of In- fectious Diseases, Shanghai Huashan Hospital Affiliated to Shanghai Fudan University, Shanghai 200040, China |
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| Abstract: | Nowadays,several epidemiologic studies have confirmed the link between hepatitis C virus(HCV) infection and diabetes mellitus, which is more obvious in those patients overweight or with an old age. The protein coded by HCV can interrupt signaling of insulin, which accounts for why patients with HCV show insulin resistance before liver cirrhosis.Meanwhile, insulin resistance accelerates the course of cirrhosis. |
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| Keywords: | Hepatitis C virus Diabetes Epidemiology |
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