The “graft versus leukemia” effect under conditions of mixed chimeric hemopoiesis |
| |
| Authors: | G V Seledtsova V I Seledtsov I V Avdeev D M Samarin V A Kozlov |
| |
| Institution: | (1) Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk |
| |
| Abstract: | The “graft versus leukemia” effect can be induced in (C57B1/6×DBA) F1 mice by two transplantations of cell suspensions containing bone marrow cells and splenocytes of (CBA×C57B1/6) F1 mice and an injection of cyclophosphamide. The recipients of cell allotransplants were characterized by mixed chimeric hemopoiesis.
These data outline a new approach to induction of the graft versus leukemia effect, requiring no complete elimination of the
recipient's hemopoiesis and characterized by a low probability of lethal graft-versus-host reaction.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 5, pp. 562–565, May, 1997 |
| |
| Keywords: | mixed chimeric hemopoiesis graft versus leukemia effect |
| 本文献已被 SpringerLink 等数据库收录！ |
