慢性阻塞性肺病患者家系呼吸驱动反应性的研究

目的　探讨慢性阻塞性肺病(COPD)Ⅱ型呼吸衰竭患者及其子女的呼吸驱动反应性的变化，并对其遗传性进行初步探讨。方法　测定6例COPDⅡ型呼吸衰竭患者及其21名子女的口腔阻断压（P

Breath drive response of COPD patients with hypercapnic respiratory failure and their families

OBJECTIVE: To investigate the breath drive response of COPD patients and their offspring and to analyze the potential heredity. METHODS: P(0.1) and ventilatory response to hypoxia (DeltaV(E)/DeltaSaO(2)), P(0.1) response to hypoxia (DeltaP(0.1)/DeltaSaO(2)), P(0.1) response to hypercapnia (DeltaP(0.1)/DeltaP(ET)CO(2)DeltaV(E)/P(ET)CO(2)) and ventilatory response to hypercapnia (DeltaV(E)/P(ET)CO(2)) were measured in 6 COPD patients with type II respiratory failure and in 21 of their normal adult offspring. RESULTS: (1) P(0.1) was remarkably higher among all of the COPD patients than among their offspring and normal controls. The hypoxia response (DeltaP(0.1)/DeltaSaO(2)) and DeltaP(0.1)/DeltaP(ET)CO(2) were significantly decreased among the COPD patients (P < 0.05). (2) The hypoxia response was low among 10 of the offspring of COPD patients, and was normal among the other 11. (3) The ventilatory response to hypercapnia (DeltaV(E)/DeltaP(ET)CO(2)) was significantly decreased among the COPD patients, and varied greatly among their offspring. CONCLUSION: (1) The depression of respiratory responses to hypoxia and hypercapnia may be the reason of type II respiratory failure. (2) The depression of hypoxia response may be influenced by genetic factors.