| 复方黄根对小鼠急性肝损伤的保护作用 |
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| 引用本文： | 邓家刚,郑作文,王勤,秦华珍,王硕,周小雷. 复方黄根对小鼠急性肝损伤的保护作用[J]. 中华中医药学刊, 2007, 25(11): 2215-2217 |
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| 作者姓名： | 邓家刚 郑作文 王勤 秦华珍 王硕 周小雷 |
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| 作者单位： | 广西中医学院,广西,南宁,530001 |
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| 摘 要： | 目的:研究复方黄根对小鼠急性肝损伤的保护作用。方法:采用四氯化碳、D-氨基半乳糖盐酸盐诱导小鼠急性肝损伤模型,观察复方黄根对小鼠血清ALT、AST活性及肝组织匀浆SOD、MDA、GSH-PX水平的影响,并观察肝组织病理学改变。结果:复方黄根可明显降低小鼠血清中ALT、AST活性,同时能减少肝匀浆MDA含量,并能使降低的肝匀浆SOD、GSH-PX活性升高。结论:复方黄根有明显的保肝作用,其保肝作用与抗脂质过氧化有关。
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| 关 键 词： | 复方黄根 急性肝损伤 保肝 |
| 文章编号： | 1673-7717（2007）11-2215-03 |
| 收稿时间： | 2007-06-15 |
| 修稿时间： | 2007-06-15 |
Protective Effects of Compound HuangGen on Acute Liver Injury |
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| DENG Jia-gang,ZHENG Zuo-wen,WANG Qin,QIN Hua-zhen,WANG Shuo,ZHOU Xiao-lei. Protective Effects of Compound HuangGen on Acute Liver Injury[J]. Chinese Archives of Traditional Chinese Medicine, 2007, 25(11): 2215-2217 |
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| Authors: | DENG Jia-gang ZHENG Zuo-wen WANG Qin QIN Hua-zhen WANG Shuo ZHOU Xiao-lei |
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| Affiliation: | Guangxi Traditional Chinese Medical University, Nanning 530001, Guangxi, China |
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| Abstract: | Objective:To investigate the protective effect of Compound HuangGen on acute liver injury in mice.Methods:The models of hepatic damage of acute were induced by CCL4,D-GalN.The ALT,AST level in serum and MDA content,SOD,GSH-PX activites in liver homogenate,Pathology of liver were observed.Results:Compound HuangGen was found to significantly decrease the serum transaminase activities,Meanwhile Compound HuangGen also decreased MDA content and prevented the reduction of SOD,GSH-PX activities in liver homogenate.Conclusion: Compound HuangGen show significant protective action on acute liver injury in mice. |
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| Keywords: | compound HuangGen acute liver injury hepatoprotection |
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