牛磺酸镁配合物保护血管内皮改善血流变学的实验研究

目的:探讨牛磺酸镁配合物保护血管内皮和改善血流变的作用。方法:冰浴加肾上腺素复制整体血管内皮损伤模型,检测血液循环内皮细胞(CEC)数量和血流变学变化,观察牛磺酸镁配合物的作用。结果:模型大鼠,CEC数量明显增加;全血比粘度增高,血液粘稠度增大,红细胞压积增大,红细胞变形能力下降,聚集能力增高;同时,血浆内皮素水平增高,一氧化氮代谢产物减少,一氧化氮合酶活性亦下降。牛磺酸镁配合物能减少模型大鼠的CEC数量;降低模型大鼠全血粘度的低切和高切变率,减少红细胞压积,提高红细胞变形能力;血浆内皮素水平下降、一氧化氮代谢产物增多、一氧化氮合酶活性增高。上述作用均呈剂量依赖性。结论:冰浴加肾上腺素法可作为整体条件下评价血管内皮损伤的模型,牛磺酸镁配合物具有血管内皮保护和血流变改善作用。

Effects of taurine-magnesium complex on vascular endothelium and hemorheology in rats in vivo

AIM: To study the protective effects of taurine-magnesium complex (TMC) on endothelium and hemorheology in rats. METHODS: A model of the endothelial damage was made by means of giving rats an injection of adrenaline and making them swim in ice-cold water, then number of circulating endothelial cells (CEC) in whole blood, plasma ET-1 and NO_2~-/NO_3~- content, NOS activity and rheology were determined, respectively. The protective effects of TMC were also observed. RESULTS: An increase in the number of CEC accompanied by abnormal whole blood viscosity, and endothelium-derived ET-1 were observed in model rats. Both the NO_2~-/NO_3~- content and NOS activity were declined significantly in model rats. TMC reduced the number of CEC, resumed NO_2~-/NO_3~- content and NOS activity, and improved the whole blood viscosity in a dose-dependent manner in model rats. CONCLUSION: Ice-cold water bath with adrenaline causes an acute damage of vascular endothelium and abnormal rheology. TMC protects against the injury of vascular endothelium and improves the hemorheology.