氟西汀联合喹硫平对重症抑郁症患者的临床疗效观察

【目的】观察氟西汀合并喹硫平对重症抑郁的治疗效果。【方法】将97例重症抑郁症患者随机分为联合组和对照组，分别给予氟西汀联合喹硫平（联合组）以及氟西汀合并安慰剂（对照组）治疗。联合组48例，氟西汀平均治疗剂量为（27．08±11．29）mg／d，喹硫平治疗剂量均为200mg／d；对照组49例，氟西汀平均治疗剂量为（38．78±9．49）mg／d，疗程共6周。采用汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HA—MA）评定疗效，副反应量表（TESS）评定不良反应。量表评定于治疗前和治疗后第1、2、4、6周末分别进行。【结果】①两组治疗后第1、2、4、6周末的HAMD和HAMA评分分别与治疗前相比，差异非常显著（P〈0．01）。②联合组与对照组的显效率分别为85．4％和77．5％，差异无显著性（P〉0．05）；联合组的氟西汀剂量显著低于对照组。③TESS量袁评定两组各测定时点分值的差异无显著性（P〉0．05）。【结论】氟西汀合并喹硫平治疗重症抑郁起效快、效果好，可降低氟西汀剂量，是治疗重症抑郁较好的方法。

Randomized Controlled Trail of Fluoxetine Combining Quetiapine in the Treatment of Patients with Major Depression Disorder

Objective] To observe the effect of fluoxetine combining quetiapine in the treatment of patients with major depression disorder. Methods] Ninety seven patients with depression were divided into 2 groups. The combination group（ n = 48） were treated with fluoxetine （27.08± 11.29） mg/d] and quetiapine （200mg/ d）. The control group（ n =49） were treated with fluoxetine（38.78±9.49） mg/d] and placebo. The course of treatment was 6 weeks. Hamilton scale for depression （HAMD） and Hamilton scale for anxiety （HAMA） were used to evaluate therapeutic efficacy, while treatment emergent symptom scale （TESS） was used to evaluate side effects. Results] The HAMD and HAMA scores in both groups decreased significantly at 1-, 2-, 4- and 6 week after treatment （ P 〈0.01）. The excellent rate of the combination group and the control group was 85.4 % and 77.5 %, respectively, but there was no significant difference between two groups. The dosage of fluoxetine in the combination group was significantly less than that in control group. TESS showed the scores in both groups were similar at each time point. Conclusion] Fluoxetine combining quetiapine for the treatment of major depression disorder had rapid onset of action and good effect. It can also reduce the dosage of fluexerine. Therefore, it is a better method for the treatment of major depression disorder.