Difficidin and oxydifficidin: novel broad spectrum antibacterial antibiotics produced by Bacillus subtilis. II. Isolation and physico-chemical characterization |
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| Authors: | K E Wilson J E Flor R E Schwartz H Joshua J L Smith B A Pelak J M Liesch O D Hensens |
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| Affiliation: | Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey. |
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| Abstract: | The isolation of difficidin (1) and oxydifficidin (2) from fermentation broth of Bacillus subtilis ATCC 39320 and the physico-chemical characterization of these labile antibiotics are described. The structures of the compounds represent a new class of antibiotics, characterized as highly unsaturated 22-membered macrolide phosphates. Difficidin and oxydifficidin undergo reversible thermal isomerization to 3 and 4 respectively. Biological evaluation of the isomers is presented. |
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