氯诺昔康与芬太尼用于下腹部术后患者自控镇痛疗效比较

目的:评价非甾体类抗炎药氯诺昔康用于下腹部手术术后患者自控镇痛(PCA)的疗效。方法:选择40例下腹部手术的患者.通过相同的麻醉方法,术后随机分为A组(n=20)和B组(n=20),进行PCA治疗。A组静脉应用氯诺昔康(2ml/h.holus为3.5ml),B组静脉应用芬太尼(2ml/h,bolus为3.5ml)。结果:下腹部手术患者术后PCA镇痛,A组(氯诺昔康组)与B组(芬太尼组)在疼痛程度(PI)、病人对镇痛治疗总体印象评分、疼痛缓解度(PAR)、用药量等方面无显著差异(P>0.05);A组总体睡眠质量略逊于B组(P<0.05);呼吸频率、皮肤瘙痒及恶心、呕吐等类似于B组。结论:氯诺昔康不失为阿片类镇痛药术后PCA的较好的替代药。

Comparision of Lornoxican and Fentanyl for Patient-Controlled Analgesia in Patients Undergoing Low Abdominal Surgery

Objective: To assess the analgesic efficacy of lornoxicam and fentanyl in the treatment of PCA. Methods: 40 patients,scheduled for elective low abdominal surgery, were randomly assigned to one of the two treatment groups. Patients in Group A were received intravenous lornoxicam ( 2 ml/h, bolus 3. 5 ml), patients in Group B were received intravenous fentanyl (2 ml/h, bolus 3. 5 ml). Results: There was no significant difference in PI, PAR, global impression score and dose between Group A and Group B(P>0. 05), however, patients in Group B experienced worse sleeping quality than those in Group A. (P<0. 05) . There was no significant difference in respiratory rate, itch,nausea and vomiting between Group A and Group B. Conclusion:Conclusion Lornoxicam was an alternative to opioids for the treatment of postoperative pain.