Adenovirus type 5 E1A-induced apoptosis in COX-2-overexpressing breast cancer cells |
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| Authors: | Takeshi Sugimoto Chandra Bartholomeusz Ana M Tari Naoto T Ueno |
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| Affiliation: | (1) Breast Cancer Translational Research Laboratory, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA;(2) Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA;(3) Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA;(4) Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA |
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| Abstract: | Introduction Suppression of Bcl-2 expression can overcome cellular resistance to apoptosis induced by the adenovirus type 5 gene E1A in models of ovarian and breast cancer. Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, is known to downregulate Bcl-2 expression. We hypothesized that celecoxib would enhance E1A-induced apoptosis by suppressing Bcl-2 through suppressing COX-2 expression. If successful, this strategy could represent a means of overcoming resistance to E1A gene therapy. |
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