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Granulocyte migration in uncomplicated intestinal anastomosis in man
Authors:A. Keshavarzian MD  MRCP  R. Gibson FRCAR  J. Guest FRCS  J. Spencer FRCS  J. P. Lavender FRCR  Dr. H. J. F. Hodgson DM  FRCP
Affiliation:(1) Departments of Medicine and Radiology, and Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, W12 OHS London, UK
Abstract:We have investigated the presence, duration, and clinical significance of granulocyte accumulation, using indium-111 granulocyte scanning, in patients following uncomplicated intestinal anastomosis. Eight patients underwent intestinal resection and anastomosis (right hemicolectomy, 5; sigmoid colectomy, 2; ileal resection, 1) for carcinoma, angiodysplasia, or perforation. All patients had an uneventful postoperative course, with no evidence of any leakage or infection. Indium-111 granulocyte scan and abdominal ultrasound were performed 7–20 days (12±4.7 X±sd) following surgery. Indium-111 granulocyte scan showed the presence of labeled granulocytes at the site of anastomosis in all patients. In three of eight, cells subsequently passed into the lumen of the bowel. In contrast, granulocytes were not visualized along the abdominal incision. Thus, in contrast to skin wounds, granulocytes continue migrating into the intestinal wall in areas of anastomosis for at least up to 20 days following surgical trauma. They may play a significant role both in healing the anastomosis and in preventing systemic bacterial infection. Moreover, indium-111 granulocyte scans following intestinal surgery should be interpreted with care, and the presence of labeled granulocytes around anastomoses does not necessarily indicate abscess formation.
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