Relationship between weakness and phase angle in advanced cancer patients with fatigue |
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Authors: | A. Navigante P. Cresta Morgado O. Casbarien N. López Delgado R. Giglio M. Perman |
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Affiliation: | 1. Translational Research Unit, Angel H. Roffo Cancer Institute, Av. San Martín 5481, Buenos Aires, Argentina 2. Department of Central Laboratory, Angel H. Roffo Cancer Institute, Buenos Aires, Argentina 3. Service of Head and Neck, Angel H. Roffo Cancer Institute, Buenos Aires, Argentina 4. Parenteral, and Enteral Nutrition Argentina Association, Buenos Aires, Argentina
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Abstract: | Objective This study aims to determine the relationship between weakness and bioimpedance analysis (BIA)-derived phase angle in a population of untreated cancer patients with fatigue. Methods We prospectively evaluated 41 treatment-naive cancer patients of several origins that presented with performance status 1–2, weight loss >5 % in the last 6 months, and Fatigue Numeral Scale score >4. Weakness was considered a physical component of the multidimensional fatigue syndrome and was evaluated through several parameters utilizing hand grip strength technique by dinamometry. The same assessment was also performed on a healthy control population (n?=?20). BIA-derived phase angle was also determined by BIA. Results Compared to healthy controls, cancer patients exhibited significant differences in all the parameters: median fatigue was 6 (range 5–9), evaluated maximal strength mean was 27?±?10.71 vs. 42?±?10.74 kg (p?0.0001 for patients vs. control, respectively), and muscle strength difference (max–min muscle strength) was also statistically different (p?0.0001). We also determined parameter associations within the patient population. We found statistical significant correlations between median phase angle score and endurance muscle with percentage of weight loss (r?=?0.43, p?=?0.03) for head and neck cancer patients, and in non-small cell lung cancer patients, grip work correlated significantly with normal or decreased phase angle (r?=?0.85), p?=?0.006 (Spearman Rank Correlation). Conclusions Weakness could be correlated with normal or decreased phase angle in a population with ambulatory advanced cancer with fatigue naive of treatment. We also found a significant relationship between median phase angle score and endurance muscle with percentage of weight loss in the subpopulation of patients with head and neck carcinoma. |
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