脑性瘫痪的危险因素分析

目的探讨新生儿缺氧缺血性脑病(HIE)继发脑性瘫痪的危险因素。方法用非条件Logistic回归分析对34例继发于HIE的脑性瘫痪患儿及同期收治的89例未并发脑瘫的HIE患儿的临床资料进行分析。结果急性期原始反射状况、1minApgar评分、临床分度、急性期CT改、急性期惊厥频率5种因素是HIE继发脑性瘫痪的主要危险因素。结论重度窒息、频繁惊厥,原始反射异常、CT改变显著及临床表现危重的HIE患儿发生脑瘫的可能性较大,应重点随访,以早期发现患儿进行治疗。

Study on Risk Factors of Cerebral Palsy secondary to Neonatal Hypoxic-ischemic Encephalopathy

Objective To identify risk factors in children with cerebral palsy（CP） secondary to Hypoxic-ischemic Encephalopathy（HIE）.Methods Nonconditional Logisti regression analysis was carried out in 34 children with CP secondary to HIE and 89 cases who underwent HIE and recovered without CP.Results 5 factors including primary reflex features,Apgar scores at 1 minute,CT findings,clinical degrees and convulsion frequency were confirmed to be the risk factors for CP by multivariate analysis.Conclusion The children with HIE,escharacterized by abnormal primary reflex,low Apgar scores at 1 minute,apparent CT findings,frequent convulsion and clinically severe degree were likely to suffer from CP.The children should be followed up specially in order to diagnose children with CP early and treat them properly.