伍用氨茶碱治疗伴有窦性心律过缓的心律失常92例临床观察

目的探讨氨茶碱联合抗心律失常药物治疗伴有窦性心律过缓的心律失常的疗效与安全性。方法观察组92例：以房性心律失常为主者服用异搏定40～80mg，每日3次；室性期前收缩为主者服用慢心律0．15～0．2g，每日3次；在此基础上加用氨茶碱0．1g每日3次，同时予以病因治疗，如应用硝酸酯类药物、血管紧张素转化酶抑制剂、营养心肌药物、抗糖尿病药物及阿司匹林等。对照组：除未用氨茶碱外，余治疗同观察组。Hoher监测2组治疗前、治疗后1个月及3个月的心律失常变化情况。结果观察组与对照组治疗房性心律失常1个月有效率分别为85．7％与62．5％，3个月有效率分别为89．8％与66．7％；治疗室性期前收缩1个月有效率分别为86．0％与61．9％，3个月有效率分别为88．4％与69．0％；2组比较差异均有显著性（均P〈0．01）。观察组治疗1个月后房性心律失常及室性期前收缩较对照组显著减少（P〈0．01）。结论对伴有轻、中度窦性心律过缓的心律失常患者采用常规抗心律失常药物加用氨茶碱治疗能明显提高疗效，且能减少严重窦性心律过缓的发生。

Effect of aminophylline in 92 patients and arrhythmias with sinus bradycardia

Objective To study the effect and safety of aminophylline and anti-arrhythmias drugs in patients with arrhythmias with sinus bradycardia.Methods 182 arrhythmias patients with sinus bradycardia were randomly divided into two groups: the observation group(n=92) and the control group(n=90).The patients of the observation group took aminophylline 0.1,three times a day,verapamil 40-80 mg,three times a day on atrial arrhythmias or mexiletine 0.15-0.2,three times a day on premature ventricular contraction as well as isosorbide dinitrate,ACEI,aspirine and drugs of anti-diabetes.The treatment of control group was the same as the observation group except without aminophylline.Effect of treating arrhythmias was watched for three months with Holter wornitor before and after treatment and side effect was recorded.Results The effective rate of observation group and the control group were 85.7% and 62.5% on the first month,89.8% and 66.7% at the third month on atrial arrhythmias and 86.0% and 61.9 at first month,88.4% and 69.0% at third month on premature ventricular contraction.There was obvious difference between two groups(P<0.01).Arrhythmias of the observation group were obviously decreased comparisedon with the control group within one month after treatment(P<0.01).Conclusion Aminophylline united routine anti-arrhythmias drugs may effeetively control arrhythmias with sinus bradycardia and reduce the occurenoe of severe sinus bradycardia.