猪减体积实验原位肝脏移植模型的建立及探讨

目的制作猪肝脏减体积原位移植模型，为临床肝脏移植提供稳定的模型基础。方法采用改良的原位肝脏移植20例，对供肝减少体积约1／3，对断面修整后，行原位移植，观察血流动力学及血液生化和温度的变化。结果手术时间（220±31）min，无肝期（35±6）min，动物术后肝功能恢复顺利，1周存活率达65％，13例动物长期存活。结论采用猪同种异体原位减体积肝脏移植模型具有操作简便，标准化程度及手术成功率高，重复性和稳定性好的优点，是大型动物肝移植系列研究的较理想动物模型，为充分利用有限的器官资源提供理论支持。

Establishment and investigation of experimental reduced size procine mode of living doner liver transplantation

Objective To establish and investigate a experimental reduced size procine mode of living doner liver transplantation. Methods Twenty domestic pigs of both sexes, weighting 25 - 30 kg, reduced size about 1/3 of orthotopic liver transplantation, the changes of hemodynamics, metabolism and temperature were investigated. Results The survival rate after one week was 65% ,operative time of recipient was （220 ±31 ） min, the recipient underwent anhepatic period of （35 ± 6 ） min. Conclusions The result indicates that the model is reliable in the study of reduced size procine mode of living doner liver transplantation.