猪减体积实验原位肝脏移植模型的建立及探讨 |
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引用本文: | 陈国勇,孙建军,曲青山,苗书斋,邢利,蔡文利.猪减体积实验原位肝脏移植模型的建立及探讨[J].中原医刊,2009(10):7-9. |
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作者姓名: | 陈国勇 孙建军 曲青山 苗书斋 邢利 蔡文利 |
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作者单位: | 郑州人民医院,450003 |
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摘 要: | 目的制作猪肝脏减体积原位移植模型,为临床肝脏移植提供稳定的模型基础。方法采用改良的原位肝脏移植20例,对供肝减少体积约1/3,对断面修整后,行原位移植,观察血流动力学及血液生化和温度的变化。结果手术时间(220±31)min,无肝期(35±6)min,动物术后肝功能恢复顺利,1周存活率达65%,13例动物长期存活。结论采用猪同种异体原位减体积肝脏移植模型具有操作简便,标准化程度及手术成功率高,重复性和稳定性好的优点,是大型动物肝移植系列研究的较理想动物模型,为充分利用有限的器官资源提供理论支持。
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关 键 词: | 肝脏移植 猪 模型 减体积 |
Establishment and investigation of experimental reduced size procine mode of living doner liver transplantation |
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Institution: | CHEN Guo - yong , SUN Jian - jun , QU Qing -shan, MIAO Shu - zhai , XING Li , CAI Wen -li.( The People's Hospital of Zhengzhou, Zhengzhou 450003, China) |
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Abstract: | Objective To establish and investigate a experimental reduced size procine mode of living doner liver transplantation. Methods Twenty domestic pigs of both sexes, weighting 25 - 30 kg, reduced size about 1/3 of orthotopic liver transplantation, the changes of hemodynamics, metabolism and temperature were investigated. Results The survival rate after one week was 65% ,operative time of recipient was (220 ±31 ) min, the recipient underwent anhepatic period of (35 ± 6 ) min. Conclusions The result indicates that the model is reliable in the study of reduced size procine mode of living doner liver transplantation. |
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Keywords: | Liver transplantation Pig Mode Reduced size |
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