血清NSE、S100B、MBP与脑梗死的临床相关性研究

目的研究急性脑梗死患者血清神经元特异性烯醇化酶（NSE）、S-100蛋白（S100B）、髓鞘碱性蛋白（MBP）浓度对其病情严重程度评估的价值。方法对62例急性脑梗死患者在病后72h内进行血清NSE、S100B、MBP浓度检测，并结合神经功能缺损评分、脑梗死体积进行比较分析。结果本组62侧脑梗死患者血清NSE、S100B、MBP浓度均显著高于正常对照组，而且病人中神经功能缺损程度不同组之间NSE、S100B、MBP浓度差异有统计学意义。分别以脑梗死后72h血清NSE浓度20μg/L、S100B浓度1．0μg／L、MBP浓度8．0μg／L为临界标准评估病情严重程度，NSE特异度为70．00％，敏感度为70．27％；S100B的特异度为75．00％，敏感度为75．68％；MBP特异度为80．00％，敏感度为64．86％；另外，脑梗死体积越大，血清NSE、S100B、MBP浓度越高。结论脑梗死后血清NSE、S100B蛋白、MBP浓度对评估患者病情严重程度具有较高的特异性和敏感性。

Research of clinical relevance of NSE,SIOOB and MBP in serum with cerebral infarction

Objective To research the value of NSE, S100B and MBP concentration on prediction of severity of illness in patients with cerebral infarction. Methods The serum concentrations of NSE, S100B and MBP were measured within 72 hours after the injury in 62 cases of patients with cerebral infarction, then making a comparative analysis by neurologic impairment score and infarct volume. Resuits The serum concentration of NSE,S100B and MBP after the injury in 62 patients with cerebral infarction increased compared with those in the normal control group obviously. Moreover, there exists significant differences in the serum concentration of NSE ,S100B and MBP between different groups that patients were in different neurologic impairment score. To assess the severity of illness by serum concentrations of NSE 20 μg/L, S100B 1.0 μg/L and MBP 8.0 μg/L after 72 hours of cerebral infarction. Specificity of NSE was 70.00%, sensitivity was 70.27% ; Specificity of S100B was 75.00%, sensitivity was 75.68% ;Specificity of MBP was 80.00%, sensitivity was 64.86%. In addition, the greater volume of cerebral infarction, the higher serum concentrations of NSE, S100B, MBP. Conclusions NSE, SIOOB and MBP may play important roles in predicting severity of illness in the patients with cerebral infarction.