食管鳞状细胞癌中COX-2、VEGF—C及CD44v6的表达与淋巴结转移的关系

目的研究食管鳞状细胞癌（简称食管鳞癌）中环氧化酶-2（COX-2）、血管内皮生长因子-C（VEGF-C）和CD44v6蛋白的表达情况及与食管癌病理特征的关系。方法采用免疫组织化学（sP）法检测58例患青食管鳞癌组织中COX-2、VEGF—C和CD44v6蛋白的表达。结果58例患者的ESCC组织中，COX-2、VEGF—C和CD44v6均呈高表达，阳性表达率分别为70．6％、53．4％、65．5％。COX-2、VEGF—C和CD44v6蛋白表达与性别、分期、分化程度无关（P均〉0．05），而VEGF—C和CD44v6与淋巴结转移正相关（P均〈0．05）。COX-2与VEGF—C、CD44v6蛋白表达无相关性（P均〉0．05）。结论COX-2、VEGF—C、CD44v6蛋白在食管鳞癌组织中呈高表达，VEGF—C、CD44v6表达与肿瘤有无淋巴结转移有关，可作为食管癌浸润、转移的重要指标。

Expression of cyclooxygenase - 2, vascular endothelial growth factor - c and CD44v6 in esophageal squamous cell carcinoma tissue

Objective To investigate the expression of cyclooxygenase - 2 （COX - 2）, vascular endothelial growth factor- c（ VEGF -C）, CD44v6 in esophageal squamous cell carcinoma（ESCC） tissue and it＇ s relation with the clinicopathalogy features. Methods The expression of COX -2, VEGF - C and CD44v6 in 58 cases of ESCC were detected by immnohistochemical staining. Rusults The positive rates of COX -2, VEGF - C and CD44v6 in ESCC tissue were 70.6% ,53.4% ,65.5% , respectively. The positive expression rates of COX - 2, VEGF - C and CD44v6 were not correlated with the degree of sex,clinical stage and differentiation（ P 〉0.05 ）,but that of VEGF- C and CD44V6 correlated remarkably with lymph metastasis （ P 〈 0.05 ）. There was no relationship between the positive expression rate of COX - 2 and VEGF - C or CD44v6 （ P 〉 0.05）. Conclusions The expression of COX - 2, VEGF -C and CD44v6 in ESCC tissue might play a role in lymphatic metastasis via lymphangiogenesis.