| 电穿孔增强核酸疫苗免疫反应的研究进展 |
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| 引用本文： | 贺奇彬,邢益平. 电穿孔增强核酸疫苗免疫反应的研究进展[J]. 国际生物医学工程杂志, 2006, 29(5): 310-312 |
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| 作者姓名： | 贺奇彬 邢益平 |
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| 作者单位： | 210029,南京医科大学第一附属医院感染病科 |
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| 摘 要： | 核酸疫苗自诞生以来在肿瘤、感染性疾病和自身免疫性疾病等方面显示出其独特的优越性。目前,研究如何增强核酸疫苗的免疫原性是一大热点,在众多方法中,电穿孔通过增加细胞对DNA的摄取,使表达的目的抗原增多,从而明显地增强了核酸疫苗诱导的免疫反应。就电穿孔技术在核酸疫苗研究领域的应用作一综述。
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| 关 键 词： | 核酸疫苗 电穿孔 免疫反应 |
| 文章编号： | 1673-4181(2006)05-0310-03 |
| 修稿时间： | 2006-02-12 |
Progress of electroporation in improving the efficacy of DNA vaccine |
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| HE Qi-bin,XING Yi-ping. Progress of electroporation in improving the efficacy of DNA vaccine[J]. International Journal of Biomedical Engineering, 2006, 29(5): 310-312 |
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| Authors: | HE Qi-bin XING Yi-ping |
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| Abstract: | DNA vaccine plays an important role in the treatment of cancer, infectious disease and self-immune disease. Further enhancement of immune responses to DNA vaccines is one of the hot spots in the vaccine development. Among the research combining the electroporation with DNA vaccination improves plasmid gene expression in vivo and significantly enhances the immune responses. This review gives an overview of the application, effectiveness and prospect of electroporation in improving the efficacy of DNA vaccine. |
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| Keywords: | DNA vaccine electroporation immune responses |
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