| Expression of AIF-1 and RANTES in Unexplained Spontaneous Abortion and Possible Association withAlloimmuneAbortion |
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| 作者姓名： | Yong-hong LI Hai-lin WANG Ya-juan ZHANG |
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| 作者单位： | Yong-hong LI1，Hai-lin WANG2，Ya-juan ZHANG2 1. Department of Gynecology and Obstetrics，The First People Hospital of Lanzhou，Lanzhou 730050，China 2. Department of Gynecology and Obstetrics，The First Affiliated Hospital of Lanzhou University，Lanzhou 730000，China |
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| 基金项目： | Acknowledgement This work was supported, in part, by the Laboratory Center for Medical Science of Lanzhou University, Department of Pathology of the First Affiliated Hospital of Lanzhou University, and Department of Pathology of the People＇s Hospital of Gansu Province （Lanzhou, China）. |
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| 摘 要： | Objective To investigate the effects of allograft inflammatory factor-1 (AIF-1) and (RANTES) in sera and deciduas on unexplained early spontaneous abortion. Methods AIF-1 and RANTES were examined in sera and deciduas/endometria of 43 unexplained early spontaneous abortion women (group A), 40 healthy women with early pregnancy(group B) and 20 healthy women with no pregnancy (group C). Immu- nohistochemistry and enzyme linked immunosorbent assay (ELISA) were used in this study. Results AIF-1 protein was expressed both in deciduas of group A and in endometria of group C. In group A, H scores in the recurrent abortion deciduas specimens were significantly greater than those in the first abortion;in endometrium, expression of AIF-1 was greater in the secretory than in proliferative phase of group C. In group B, concentrations of RANTES in sera were higher in 7th-8th week of pregnancy than in 6th-7th and >8th week of pregnancy; expression of AIF-1 protein showed a negative correlation with RASNTES concentration; a significant increase of the RANTES levels in sera and tissue was observed in group B. Conclusion These results demonstrate, for the first time, that AIF-1 are expressed in deciduas of unexplained spontaneous abortion suggesting that AIF-1 involve in alloimmune abortion; RANTES might act as a novel blocking antibody;AIF-1 and RANTES might act as reliable markers for diagnosis of early alloimmune abortion.
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| 关 键 词： | 意外流产 同种免疫 AIF-1 封闭性抗体 |
| 收稿时间： | 2007-02-02 |
Expression of AIF-1 and RANTES in Unexplained Spontaneous Abortion and Possible Association with Alloimmune Abortion |
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| Yong-hong LI Hai-lin WANG Ya-juan ZHANG.Expression of AIF-1 and RANTES in Unexplained Spontaneous Abortion and Possible Association withAlloimmuneAbortion[J].Journal of Reproduction and Contraception,2007,18(4):261-270. |
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| Authors: | Yong-hong LI Hai-lin WANG Ya-juan ZHANG |
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| Institution: | 1. Department of Gynecology and Obstetrics, The First People Hospital of Lanzhou, Lanzhou 730050, China
2. Department of Gynecology and Obstetrics, The First Affiliated Hospital of Lanzhou University, Lanzhou 730000, China |
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| Abstract: | Objective To investigate the effects of allograft inflammatory factor-1 (AIF-1) and (RANTES) in sera and deciduas on unexplained early spontaneous abortion. Methods AIF-1 and RANTES were examined in sera and deciduas/endometria of 43 unexplained early spontaneous abortion women (group A), 40 healthy women with early pregnancy(group B) and 20 healthy women with no pregnancy (group C). Immu- nohistochemistry and enzyme linked immunosorbent assay (ELISA) were used in this study. Results AIF-1 protein was expressed both in deciduas of group A and in endometria of group C. In group A, H scores in the recurrent abortion deciduas specimens were significantly greater than those in the first abortion;in endometrium, expression of AIF-1 was greater in the secretory than in proliferative phase of group C. In group B, concentrations of RANTES in sera were higher in 7th-8th week of pregnancy than in 6th-7th and >8th week of pregnancy; expression of AIF-1 protein showed a negative correlation with RASNTES concentration; a significant increase of the RANTES levels in sera and tissue was observed in group B. Conclusion These results demonstrate, for the first time, that AIF-1 are expressed in deciduas of unexplained spontaneous abortion suggesting that AIF-1 involve in alloimmune abortion; RANTES might act as a novel blocking antibody;AIF-1 and RANTES might act as reliable markers for diagnosis of early alloimmune abortion. |
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| Keywords: | unexplained spontaneous abortion alloimmune AIF- 1 RANTES blocking antibody |
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