Insulin-like growth factor II receptor gene-167 genotype increases the risk of oral squamous cell carcinoma in humans |
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Authors: | Zavras Athanasios I Pitiphat Waranuch Wu Tianxia Cartsos Vassiliki Lam Albert Douglass Chester W Diehl Scott R |
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Affiliation: | Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA. |
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Abstract: | Our purpose was to evaluate inherited short tandem repeat polymorphisms of the insulin-like growth factor II receptor gene (IGF2R) in oral cancer risk. The 197 individuals that consented to participate in a hospital-based, case-control study were interviewed with a structured questionnaire and provided blood and saliva. DNA was extracted for genotyping using a PCR-based method. Odds ratios were calculated using multivariate logistic regression. Subjects carrying the heterozygous 167-bp IGF2R genotype had a 2.7-fold higher risk of oral cancer compared with subjects with other genotypes (odds ratio = 2.7, 95% confidence interval: 1.16-6.48), controlling for major confounders. Our results suggest that genetic variation of IGF2R may influence significantly the risk of oral cancer. |
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