安宫牛黄丸的药理及临床研究进展

作为久负盛名的中药急救药品,安宫牛黄丸协同其他疗法对脑炎,中风,脑出血、脑缺血性损伤等脑病及所导致的高热昏迷有独特的疗效,现代药理实验表明安宫牛黄丸对大鼠急性期脑出血、脑缺血损伤有较好的保护作用,对闭合性脑损伤大鼠的脑水肿、脑缺血缺氧状态等有一定的积极作用,另外安宫牛黄丸对脓毒症大鼠也有一定的干预作用。但由于安宫牛黄丸组方中含有雄黄(砷)和朱砂(汞),其安全服用尤为重要,本文从安宫牛黄丸的现代药理作用、临床应用等方面阐述它的研究现状,旨在为合理应用安宫牛黄丸提供新的思路和参考。

Recent Pharmacologic Actions and Clinical Applications of Angong Niuhuang Wan

As a famous traditional Chinese medicine, Angong Niuhuang Wan is used for treatment of various diseases, such as encephalitis, apoplexy, cerebral hemorrhage, ischemic cerebral injury and so on. It also has unique effect on coma, hyperpyrexia induced by cerebral diseases. Pharmacology studies on Angong Niuhuang Wan reveal its versatile activities on encephalopathy, like cerebral hemorrhage, ischemia injury, sepsis and so on in animals. The safe application of Angong Niuhuang Wan appears to be utmost important due to the contained realgar (As) and cinnabar (Hg). This article describes the progress in studies of Angong Niuhuang Wan, including pharmacologic actions and clinical applications, to provide a new thinking and reference to the further utilization of Angong Niuhuang Wan.