| 蛋白酶激活受体-2在子宫内膜异位症组织中的表达及意义 |
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| 引用本文： | 李辅维,周春. 蛋白酶激活受体-2在子宫内膜异位症组织中的表达及意义[J]. 武汉大学学报(医学版), 2011, 32(4): 457-459,封2 |
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| 作者姓名： | 李辅维 周春 |
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| 作者单位： | 武汉大学中南医院妇产科,湖北武汉,430071 |
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| 摘 要： | 目的:探讨蛋白酶激活受体-2(PAR-2)在子宫内膜异位症组织中的表达及意义.方法:应用SP免疫组织化学法检测30例异位子宫内膜、10例正常子宫内膜的PAR-2表达.结果:PAR-2在子宫内膜上皮细胞和间质细胞中均有表达.异位子宫内膜内PAR-2呈强阳性表达;正常子宫内膜内PAR-2呈弱表达.图像分析结果显示异位子宫内...
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| 关 键 词： | 子宫内膜异位症 免疫组织化学 蛋白酶激活受体-2 |
Expression and Significance of Proteinase Activated Receptor-2 in Endometriosis |
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| LI Fuwei,ZHOU Chun. Expression and Significance of Proteinase Activated Receptor-2 in Endometriosis[J]. Medical Journal of Wuhan University, 2011, 32(4): 457-459,封2 |
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| Authors: | LI Fuwei ZHOU Chun |
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| Abstract: | Objective:To investigate the expression and significance of proteinase activated receptor-2(PAR-2) in endometriosis.Methods:The expression of PAR-2 was detected by immunohistochemistry streptavidin-peroxidase(SP) method in the endometrial tissue of 30 cases of ectopic endometriosis and 10 samples of normal endometrium.Results:The expression of PAR-2 was mainly in the endometrial epithelium and stroma locating in cytoplasm.The expression of PAR-2 was more significant in ectopic endometrium than in normal control.The result of image analysis suggested that mean optical density was 0.221 4±0.010 8 in ectopic endometriosis group versus 0.058 1±0.010 2 in control group,and positive area ratio was 0.135 1±0.032 1 and 0.062 3±0.011 2 respectively in the two groups(both P<0.01).Conclusion:These findings suggested that PAR-2 may play a critical role in the pathophysiology and development of endometriosis,and PAR-2 may be a new target for endometriosis therapy in the future. |
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| Keywords: | Endometriosis Immunohistochemistry Proteinase Activated Receptor-2 |
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