Refractory autoimmune thrombocytopenic purpura: responses to treatment with a recombinant antibody to lymphocyte membrane antigen CD20 (rituximab) |
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Authors: | Narang Mohit Penner John A Williams Dan |
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Institution: | Michigan State University, Department of Medicine, Division of Hematology/Oncology, East Lansing, Michigan 48824, USA. |
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Abstract: | "Refractory" autoimmune thrombocytopenia represents a life-threatening condition, having failed to respond to a variety of therapeutic measures. We report a series of cases, all failing splenectomy and multiple therapeutic programs, including, in two patients, marrow transplant. Five of the six cases reported responded to a recombinant antibody to the lymphocyte membrane antigen CD20 (rituximab), an agent commonly employed in the treatment of non-Hodgkin's lymphoma. Our experiences over a period of 4 years are documented. The results support the use of this product, rituximab, in the treatment of patients with autoimmune thrombocytopenia who have not attained a hemostatically effective platelet count following splenectomy and require a continuing therapeutic management program. |
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Keywords: | thrombocytopenia immune idiopathic thrombocytopenic purpura (ITP) rituximab refractory ITP Rituxan® |
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