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Long-term protective immune response elicited by vaccination with an expression genomic library of Toxoplasma gondii |
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| Authors: | Fachado Alberto Rodriguez Alexandro Molina Judith Silvério Jaline C Marino Ana P M P Pinto Luzia M O Angel Sergio O Infante Juan F Traub-Cseko Yara Amendoeira Regina R Lannes-Vieira Joseli |
| Affiliation: | Laboratory of Autoimmunity and Immunoregulation, Department of Immunology, Oswaldo Cruz Institute, Rio de Janeiro, Brazil. |
| Abstract: | Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to 117 kDa) and long-term protective immunity against a lethal challenge. These results support further investigations to achieve a multicomponent anti-T. gondii DNA vaccine. |
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