| 卵巢早衰外周血B细胞及T细胞亚群的研究 |
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| 引用本文： | 方群,梁贵尚,谭路坚. 卵巢早衰外周血B细胞及T细胞亚群的研究[J]. 中山大学学报(医学科学版), 1993, 0(3) |
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| 作者姓名： | 方群 梁贵尚 谭路坚 |
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| 作者单位： | 中山医科大学附属第一医院妇产科(方群，梁贵尚)，中山医科大学附属第一医院内科(谭路坚) |
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| 摘 要： | 对25例继发性高促性腺素、低雌激素状态下的卵巢早衰(POF)患者,检测其外周血B淋巴细胞数及T细胞亚群,与18例正常育龄妇女作对照;并与12例原发性卵巢性闭经(原发闭经)患者进行对照。结果显示:POF组的B细胞数为19.16％,原发性闭经组为21.18％,均显著高于正常组的14.83％。提示B细胞的增多可能与患者体内自身免疫性抗体的增多有关。此外,雌激素缺乏可能与B细胞的增多也有关。原发闭经组T_8亚群为27.27％,显著高于POF组的23.08;T_4/T_8在原发闭经组的比值为1.48显著低于POF组的1.93及正常组的1.81。提示POF患者与原发性卵巢性闭经的患者虽同处于低雌激素状态,但其T细胞亚群分布有所不同。从而提示两组患者的细胞免疫状态可能不同。
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| 关 键 词： | 卵巢早衰 淋巴细胞亚群 闭经 |
B LYMPHOCYTE AND T LYMPHOCYTE SUBSETS IN PATIENTS WITH PREMATURE OVARIAN FAILURE |
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| Fang Qun Liang Guishang Tang Lujiang. B LYMPHOCYTE AND T LYMPHOCYTE SUBSETS IN PATIENTS WITH PREMATURE OVARIAN FAILURE[J]. Journal of Sun Yatsen University(Medical Sciences), 1993, 0(3) |
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| Authors: | Fang Qun Liang Guishang Tang Lujiang |
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| Abstract: | B lymphocyte and T lymphocyte subsets were investigated in 25 patients with premature ovarian failure (POF), which had secondary hypergonadotropin and hypoestr-ogen. The results were compared with both 18 normal women in childbearing age and 12 patients with primary ovarian amenorrhea. The B cell in POF group was 19.16%, significantly higher than 14.83% in normal group. In addition, the B cell was also higher in primary ovarian amenorrhea (21.18%) than in normal group (14.83%). The results showed that the increase of B cell might result in enhancement of autoantibodies. Besides, estrogen deficiency was probably related to the increase of B cell.In the patients with primary ovarian amenorrhea, T8 was 27.27%, significantly higher than 23.08% in POF; T4/T8 was 1.48, lower than 1.93 in POF and 1.81 in normal group. It suggested that the T lymphocyte subsets be different between the patients with POF and with primary ovarian amenorrhea, though existing estrogen deficiency in both groups. |
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| Keywords: | premature ovarian failure lymphocyte subsets amenorrhea |
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