HBIG及乙肝疫苗联合应用阻断乙肝母婴传播效果分析

目的 :研究乙型肝炎免疫球蛋白 (HBIG)和乙型肝炎疫苗联合应用对乙型肝炎产后母婴传播阻断作用及对出生时已感染乙肝病毒新生儿乙型肝炎表面抗原阴转的效果。方法 :选择 6 8例乙型肝炎表面抗原 (HBsAg)及乙型肝炎e抗原 (HBeAg)双阳性母亲所产新生儿 ,于产后 4h～ 6h乙肝疫苗免疫接种前抽股静脉血检测HBsAg和HBeAg ,新生儿于 6h和 1月龄分别注射HBIG 10 0IU ,并按 0 ,1,6 (5 μg)方案注射乙型肝炎疫苗 ,于 1岁龄复查HB sAg和HBeAg。结果 :新生儿HBsAg和HBeAg双阳性 2 5例占 36 .76 % ,HBeAg单阳性 1例 1.4 7% ,HBsAg单阳性 18例占 2 6 .4 7% ,HBsAg和HBeAg双阴性 2 4例占 35 .2 9% ;1岁龄HBsAg转阴 19例占 4 3.18% ,其中HBsAg和HBeAg双阳性转阴性 4例 ,HBsAg单阳性转阴性 15例。HBsAg阴性转阳性 2例占 8.33%。结论 :人HBIG和乙型肝炎疫苗联合应用能有效阻断乙型肝炎因母婴接触、母乳喂养引起的传播 ,有效率为 91.6 7% ;并使已感染乙肝病毒新生儿的HBsAg转阴率达到 4 3.18%。

The Effect Assay of HBIG and HB Vaccine Used on the Interruptive Mother-to-baby Transmission of HB

Objective To study the interruptive f unction of both hepatitis B immu ne globulin (HBIG) and hepatitis B (HB) vaccine’s jointly use on the mother-to- baby transmission of HB at the postpartum,and also the effect of HB surface anti gen (HBsAg)’s negative change on HB virus-infected neonates. Method Choose 68 n eonates whose mothers are with double positive HBsAg and HB e antigen (HBeAg) as examples.Assay HBsAg and HBeAg by collecting the femoral vein blood between 4～ 6 hours of the postpartum before the inoculation of HB vaccine,Inject HBIG 100 IU respectively into neonates in their 6-hours and 1-month age.Inject HB vaccine ac cording to the 0,1,6(5 g) schemes,and reexamine HBsAg and HBeAg in their 1-yea r age. Results 25 samples are positive HBsAg and HBeAg the neonates and the double positive rate occupies 36.76 %,one samples of HBeAg single positive rate occupi e s 1.47 %.18 samples of HBsAg single positive rate occupies 26.47%.24 samples HBs Ag and HBeAg double negative rate occupies 35.29 %;19 samples of HBsAg turned to n egative ones occupies 43.18 % in 1-year-old neonates.Among them,4 HBsAg and HB eAg the double positive samples turned to negative ones,15 HBsAg single positive sa mples turned to negative ones.2 samples of negative HBsAg turned to positive one s occupies 8.33 %. Conclusion The jointly use of HBIG and HB vacc ine can interrup t the transmission of HB effectively which is because of the mother-to-baby co nt act and the mother’s milk feeds,and the effective rate is 91.67%.Make HB that h as already been infected with the neonates’ HBsAg turn to negative one,and the rate has been up to 43.18 %.