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Three different LDL apheresis columns efficiently and equally reduce lipoprotein(a) concentrations in patients with familial hypercholesterolemia and small apolipoprotein(a) particles |
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| Authors: | Anders Hovland,Santica MarcovinaRandolf Hardersen,Terje EnebakkTom Eirik Mollnes,Knut Tore Lappegå rd |
| Affiliation: | a Coronary Care Unit, Division of Internal Medicine, Nordland Hospital, Bodø, Norway b Institute of Clinical Medicine, University of Tromsø, Norway c Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, WA, United States d Dialysis Unit, Division of Internal Medicine, Nordland Hospital, Bodø, Norway e Somatic Research Laboratory, Nordland Hospital, Bodø, Norway f Institute of Medical Biology, University of Tromsø, Norway |
| Abstract: | IntroductionHigh levels of lipoprotein(a) [Lp(a)] and apolipoprotein(a) [apo(a)] are associated with cardiovascular disease. In this study we determined apo(a) particle size and compared the Lp(a) reducing efficacy of three different LDL apheresis columns; DL-75, LA-15 and EC-50W in patients with familial hypercholesterolemia (FH).ResultsAverage Lp(a) concentration was reduced by 70%, 74% and 75% (all p < 0.0001) for DL-75, LA-15 and EC-50W, respectively. No significant changes in the relative proportion of the isoforms of 14 and 32 K 4 domains were observed after apheresis.ConclusionThree different LDL apheresis columns reduced Lp(a) efficiently with preserved ratio between apo(a) isoforms. |
| Keywords: | Familial hypercholesterolemia LDL apheresis LDL cholesterol Lipoprotein(a) Atherosclerosis |
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