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Quality-assessments of characteristics of placental/umbilical cord blood associated with maternal age- and parity-related factor |
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| Authors: | Atsuko Omori Masako Hirai Takako ChibaKenji Takahashi Satoru YamaguchiTsuneo A. Takahashi Ikuo Kashiwakura |
| Affiliation: | a Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki 036-8564, Japan b Cell Therapy Research and Development Laboratory, New York Blood Center, NY, USA c Yamaguchi Hospital, 5-24-2 Nishifunabashi, Funabashi, Chiba 273-0031, Japan |
| Abstract: | Umbilical cord blood (CB) has been widely used for unrelated allogeneic stem cell transplantation. It is important to determine the quality of CB units to avoid frequent problem of limited cell yields. However, no practical and/or optimum obstetric factors to predict them are yet available. This study analyzed the relationship between maternal/neonatal obstetric factors and the laboratory parameters of CB units to identify the optimum factors associated with a high yield of total nucleated cells (TNC). Primiparae in their early 30s may be one of the first selection criteria for CB donors to obtain higher yield of TNC. |
| Keywords: | Cord blood CD34+ cells Maternal age Primiparae TNC |
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