| 川芎嗪对大鼠被动型Heymann肾炎病变的影响 |
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| 引用本文： | 王迎伟,汤仁仙,董红燕. 川芎嗪对大鼠被动型Heymann肾炎病变的影响[J]. 基础医学与临床, 2000, 20(1): 74-76 |
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| 作者姓名： | 王迎伟 汤仁仙 董红燕 |
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| 作者单位： | 1. 江苏徐州医学院电镜室,徐州,221002
2. 江苏徐州医学院免疫教研室 |
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| 摘 要： | 建立ＳＤ大鼠典型的被动型Ｈｅｙｍａｎｎ肾炎（ＰＨＮ）模型，观察川芎嗪对肾内血栓素Ａ２（ＴｘＡ２）．前列环素Ｉ２（ＰＧＩ２）及ＴＸＡ２－ＰＧＩ２平衡的影响。结果表明：川穹嗪能够降低大鼠尿中的ＴＸＡ２而提高ＰＧＩ２的含量。此外，对于减少尿蛋白的分泌及肾组织学的损伤也有一定的作用。提示川芎嗪可用于ＰＨＮ病变的防治。
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| 关 键 词： | Heymann肾炎 川芎嗪 血栓素 前列环素 |
Effect of ligustrazine on pathologic changes of passive Heymann nephritis in rat |
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| WANG Ying-wei, TANG Ren-xian , DONG-Hong-yan. Effect of ligustrazine on pathologic changes of passive Heymann nephritis in rat[J]. Basic Medical Sciences and Clinics, 2000, 20(1): 74-76 |
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| Authors: | WANG Ying-wei TANG Ren-xian DONG-Hong-yan |
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| Abstract: | The animal model of typical passive Heymann nephritis(PHN ) was established on SD rats by using antibody against Heymann antigen. The effect of Ligustrazine on the renal damage was studied during the experimental period. The results showed that ligustrazine inhibited the production of renal thromboxane A, (TxA, ) and enhanced the synthesis of prostacycling I2 (PGI2) and promoted the restoration of TxA2 -PGI2 balance in rats.lt indicated that Ligustrazine coule not only reduce urinary thromboxane production and elevated the level of 6-keto-PGFI a, but also lower the urinary protein excretion and reduce the renal tissue injuries. |
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| Keywords: | Heymann nephritis ligustrazine thromboxane prostacycline |
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