氢质子磁共振波谱在原发性癫癎中的应用研究

目的：应用氢质子磁共振波谱(proton magnetic resonance spectroscopy, 'H-MRS)检测癫癎患儿的脑组织生化代谢物，探讨'H-MRS在原发性癫癎中的临床应用价值及意义。方法：对33例原发性癫癎患儿（癫癎组，其中14例有热性惊厥史）和6例正常儿童（对照组）进行常规头颅MRI和颞叶海马区的'H-MRS检查。检测N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)和乳酸(Lac)的信号强度，计算并比较NAA/（Cho+Cr）和Lac/Cr的比值。结果：头颅MRI检查：除1例癫癎患儿表现为髓鞘发育不良外其余所有研究对象均无异常。'H-MRS检测：NAA/（Cho+Cr）比值在癫癎组为0.64±0.07,低于对照组(0.73±0.05)（P＜0.01）；同时伴有热性惊厥史的癫癎患儿为0.61±0.07，低于不伴有热性惊厥史的癫癎患儿（0.66±0.06）（P＜0.05）。癫癎组Lac/Cr比值与对照组差异无统计学意义。结论：'H-MRS作为一项无创的检查，能更敏感地发现癫癎患儿的早期脑损伤，为癫癎的诊断和评估预后提供客观依据。［中国当代儿科杂志，2010，12（6）：425-428］

Clinical application of proton magnetic resonance spectroscopy in children with idiopathic epilepsy

Objective This study examined the biochemical metabolism by proton magnetic resonance spectroscopy('H-MRS)in order to explore the value of 'H-MRS in idiopathic epilepsy in children.Methods Thirty-three children with idiopathic epilepsy(14 cases with history of febrile seizures and 19 cases without)and six normal controls experienced MRI of the skull and brain and single-voxel 'H-MRS examinations of the hippocampi-temporal lobe.The signal intensities of N-acetylaspartate(NAA),eatine+phosphocreatine(Cr),choli...