IL-10 inhibits prostaglandin E2 production by lipopolysaccharide-stimulated monocytes |
| |
| Authors: | Niiro, Hiroaki Otsuka, Takeshi Kuga, Seiji Nemoto, Yoshiaki Abe, Masayoshi Hara, Nobuyuki Nakano, Teruaki Ogo, Tomonori Niho, Yoshlyuki |
| |
| Affiliation: | The First Department of internal Medicine Fukuoka 812, Japan
1 Research institute for Diseases of the Chest, Faculty of MediciTie, Kyushu University Fukuoka 812, Japan |
| |
| Abstract: | Since IL-10 has recently been shown to exhibit plelotroplc effectson human monocytes, It was of interest to determine the effectof this cytoklne on prostaglandin E2 (PGEJ production by monocytes.Recomblnant IL-10 (rlL-10) did not significantly affect PGE2production by lipopolysaccharide (LPS)-unstimulated monocytes,but efficiently inhibited PGE2 production by LPS-stlmulatedmonocytes. The inhibition by rlL-10 was achieved in a dose-dependentmanner. Recombinant IL-4 also inhibited PGE2 production at thesame degree as rlL-10. Viral IL-10 Inhibited PGE2 productionby monocytes in a similar fashion as did human rlL-10. Endogenouslyproduced IL-10 was also shown to inhibit PGE2 production byLPS-stlmulated monocytes. Kinetic studies showed that the inhibitionby rlL-10 on PGE2 production was observed at least 3 h afterLPS stimulation. Taken together, these results indicate thatIL-10 may play an important role in modulating immunologlcalresponses via down-regulation of PGE2 production by monocytes. |
| |
| Keywords: | IL-10 lipopolysaccharide monocyte prostaglandin E2 |
| 本文献已被 Oxford 等数据库收录！ |
|
