MELAS, Myoclonus, Ataxia and Deficiencies of Complexes I and IV in Muscle Mitochondria |
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Authors: | Reiko Yamanaka M.D. Yoshiko Nomura M.D. Masaya Segawa M.D. Ikuya Nonaka M.D. |
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Affiliation: | Department of Pediatrics, Shida General Hospital ofFujieda, Shizuoka;*Segawa Neurological Qinic for Children, Tokyo;**National Center for Nervous, Mental and Muscular Disorders, Tokyo |
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Abstract: | A 13-year-old Japanese girl developed convulsions, periodic attacks of coma with hyperpyrexia, visual disturbance, aphasia, myoclonus, cerebellar symptoms and dementia. A muscle biopsy four years previously had shown ragged-red fibers. Biochemical studies showed NADH CoQ reductase and cytochrome c oxidase deficiencies in biopsied muscle at 13 years of age, although normal activity of cytochrome c oxidase had been histochemically detected at 9 years of age. A therapeutic trial of citrate administration produced transient improvement in the clinical features and in the hyperlactic and pyruvic acidemia. |
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Keywords: | Mitochondrial encephalomyopathy MELAS Deficiencies of Complex I and IV Myoclonus Citric acid |
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