| 摘 要： | Nuclear DNA content of malignant cells was measured by OPTON III microspectrophotometry in 19 cases of hepatocellular carcinoma (HCC), as well as cells from the paraneoplastic liver tissue. The mean DNA value increased greatly from non-liver cells dysplasia (LCD), LCD to HCC (P<0. 05—0. 01), In histograms, non-LCD hepatocytes showed a single peak type located at 2C. HCC showed lower multiple peaks which migrated to 4C and spread widely with more aneuploid (>5C) cells, This histograms of LCD were between non-LCD and HCC,and there were also some aneuploid cells in LCD. These results indicate that LCD is a group of proliferating cells and those with relatively high ratio of aneuploid cells might be premalignant. Recently, many reports on analysis of nuclear DNA content of esophageal, gastric, nasopharyngeal and lung cancer, as well as cells of precancerous lesions have been published. Most results showed that nuclear DNA content of the conditions above mentioned and their number of chromsome were often alterated. Analysis on nuclear DNA content of hepatocellular carcinoma (HCC) and liver cell dysplasia (LCD) are vary rare. And so far, there have been various considerations on behavor of LCD and its relationship to HCC. We would attempt to further approach biologically nature of LCD and its association with HCC by measuring nuclear DNA content.
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