Cytotoxic diterpenoids from the hybrid soft coral Sinularia maxima x Sinularia polydactyla |
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| Authors: | Kamel Haidy Nasr Ferreira Daneel Garcia-Fernandez Luis F Slattery Marc |
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| Institution: | Department of Pharmacognosy, and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA. hnkamel@olemiss.edu |
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| Abstract: | Chemical investigation of the hybrid soft coral Sinularia maxima x Sinularia polydactyla yielded four new cembranolide diterpenes (1-4), the norcembranoid 5-episinuleptolide (5), and two known sesquiterpenes. The structures and configurations of the new compounds were determined by spectroscopic techniques and comparison of NMR data with those of related metabolites. Compound 3 shows strong cytotoxicity on the breast cancer SK-BR3 cell line and cervix cancer HeLa and HeLa-Apl cell lines with GI(50) values of 0.039, 0.48, and 0.56 microM, respectively. |
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