焦虑障碍患者的客观睡眠与临床特征相关性研究

目的 探讨焦虑障碍患者睡眠状况的一般特点以及与临床症状之间的关系.方法 运用病例对照研究方法分析32例焦虑障碍患者和30例健康对照人群的整夜多导睡眠图差异,并与临床症状进行相关分析.结果 与正常对照组比较,焦虑障碍患者表现为睡眠效率下降(P<0.05),睡眠潜伏期时间延长(P<0.05),非快动眼睡眠阶段百分比增加(P<0.01),快动眼睡眠阶段时限减少(P<0.01),以及快动眼睡眠阶段百分比下降(P<0.01).非快眼动睡眠第Ⅱ期睡眠百分比与汉密尔顿焦虑量表总分成正相关(r=0.356,P<0.05),与精神焦虑因子分成正相关(r=0.448,P<0.05).结论 焦虑障碍存在多项客观睡眠指标异常,且临床焦虑症状程度与客观睡眠指标具有相关性.因此,进一步结合神经生化、神经影像学等深入研究,对于探讨该病的病理机制具有一定价值.

Correlation between objective sleep and clinical features in patients with anxiety disorders

Objective To explore the general characteristics of sleep in anxiety disorder patients and the relationship between sleep sta -tus and clinical symptoms.Methods A case-control study was conducted to analyze the difference in polysomnography between 32 pa-tients with anxiety disorders and 30 normal controls,and to analyze the clinical symptoms.Results Compared with normal control group,patients with anxiety exhibited disorders decreased sleep efficiency(P<0.05),prolonged sleep latency(P<0.05),non REM sleep stages increased(P<0.01),REM sleep stage time(P<0.01),and reduced the REM sleep stage percentage(P<0.01).The percentage of II sleep in REM sleep was positively related to the Hamilton Anxiety Scale(r=0.356,P<0.05),and was positively re-lated to mental anxiety factors(r=0.448,P<0.05).Conclusions There are many objective sleep indexes in anxiety disorder,and the degree of clinical anxiety is correlated with objective sleep index.Therefore,it is valuable to further investigate the pathological mecha-nism of the disease by further studying the biochemistry,neuroimaging and so on.