早发冠心病患者危险因素分析及冠脉病变特点研究

目的 探讨早发冠心病患者危险因素及冠状动脉病变特点.方法 入选该院2014年6月-2016年4月经冠状动脉造影诊断为冠心病的患者103例,根据年龄(男≤55岁,女≤65岁)分为早发组(49例)和对照组(54例),对两组患者的一般资料、生化指标、吸烟饮酒史、早发家族史、高血压、糖尿病病史及冠状动脉病变情况进行统计学分析.结果 两组患者在吸烟史及早发冠心病家族史方面,早发组高于对照组,而早发组高血压患者比例小于对照组(P<0.05);早发组三酰甘油、总胆固醇、高密度脂蛋白胆固醇、尿酸、纤维蛋白原及同型半胱氨酸明显高于对照组;早发组单支病变明显多于对照组,而三支病变、回旋支及右冠脉病变明显低于对照组(P<0.05);多因素Logistic回归分析显示,早发冠心病家族史、吸烟、高血压是早发冠心病的独立危险因素.结论 早发家族史、吸烟、高血压、脂质代谢紊乱、尿酸、纤维蛋白原及同型半胱氨酸是早发冠心病主要危险因素,早发冠心病冠脉病变以单支病变为主,早期干预对减少早发冠心病发病率意义重大.

The analysis of risk factors and coronary artery lesions in patients with premature coronary heart disease(PCHD)

Objective To explore the risk factors and coronary artery lesions in patients with PCHD.Methods 103 patients were diag-nosed CHD by coronary angiography from June 2014 to April 2016 in our hospital.Patients were divided into PCHD group(49 cases) and control group(54 cases)according to age(male≤55 years old and female≤65 years old).We conducted a statistical analysis of general information,biochemical parameters,smoking and drinking history,family history of early onset,hypertension history of diabetes mellitus and coronary artery lesion.Results In the two groups of patients,smoking history and early onset of coronary heart disease family history,the PCHD group was higher than the control group.In hypertension,the PCHD group was lower than the control group(P<0.05).The levels of triglyceride,total cholesterol,high-density lipoprotein cholesterol,uric acid,fibrinogen and homocysteine in the PCHD group were significantly higher than those in the control group.The incidence of single vessel disease in the PCHD group was sig-nificantly higher than that in the control group,while the three-vessel disease,the circumflex artery and the right coronary artery disease were significantly lower than those in the control group(P<0.05).Multivariate logistic regression analysis showed that family history of PCHD,smoking and hypertension were independent risk factors for PCHD.Conclusions Family history of premature coronary heart disease,smoking,hypertension,lipid metabolic disorders,uric acid,fibrinogen and homocysteine are the main risk factors of PCHD.The PCHD group ispredominantly single-vessel disease,early intervention to reduce the incidence of PCHD is of great significance.