降纤酶对缺血性脑卒中急性期血浆VEGF等4项生物分子的影响

目的：观察降纤酶治疗早期缺血性脑卒中前后血浆中血管内皮生长因子（vascular endothelial growth factor VEGF）、内皮素（endothelin ET-1）、P-选择素（P-selectin）和血小板活化因子（platelet activating factor PAF）水平的变化，并探讨其机理。方法：随机将114例急性缺血性脑卒中患者分为降纤酶组和对照组，观察其临床疗效，检测凝血功能和VEGF、ET-1、P-seleetin、PAF等4项生物分子水平的变化。结果：治疗后2组临床疗效经Ridit分析差异无统计学意义（P〉0．05），2种药物对凝血功能和4项血浆生物分子水平的影响差异有统计学意义（P〈0．01），降纤酶抗凝明显，且能降低Fbg水平，对ET-1、P-seleetin和PAF有抑制作用，能提高VEGF的血浆含量。低分子肝素钠抗凝明显，也能降低Fbg水平，对PAF有抑制作用。结论：降纤酶可提高血浆VEGF水平，抑制血浆ET-1、P-selectin和PAF的合成。

Effects of defibrinogenase on four plasm biomoleculs levels in acute cerebral infarction

Objective: To explore the changes of plasma vascular endothelial growth factor(VEGF),endothelin(ET-1),P-selectin and platelet activating factor(PAF)in patient with ischemic stroke treated with defibrinogenase.Method: The blood coagulation function and the concentration of VEGF,ET-1,P-selectin and PAF were determined in acute cerebral infarction in 66 patients with defibrinogenase and 48 with low dose heparin before and after treatment.Result: Excluding curative effect,there was significant difference between the two groups on the blood biochemicals items and plasm biomoleculs levels.The Fbg decreased,the level of ET-1,P-selectin and PAF were depressed,and the plasm VEGF level rised in the defibrinogenase group,whereas only Fbg and the plasm PAF were depressed by low dose heparin.Conclusion: Defibrinogenase seems to have a salutary effect on descending of the Fbg,rising of the plasm VEGF levels and depressing of the synthesis of the ET-1,P-selectin,and PAF.