| 大鼠脑出血后Fas表达与神经细胞凋亡的关系及氟桂利嗪的干预作用 |
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| 引用本文： | 李建设,白宏英,王金兰,杨霄鹏,苏建. 大鼠脑出血后Fas表达与神经细胞凋亡的关系及氟桂利嗪的干预作用[J]. 中国实用神经疾病杂志, 2009, 12(3) |
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| 作者姓名： | 李建设 白宏英 王金兰 杨霄鹏 苏建 |
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| 作者单位： | 郑州大学第二附属医院,郑州,450014;郑州大学第二附属医院,郑州,450014;郑州大学第二附属医院,郑州,450014;郑州大学第二附属医院,郑州,450014;郑州大学第二附属医院,郑州,450014 |
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| 摘 要： | 目的 观察大鼠脑血肿周围脑组织Fas的表达和神经细胞的凋亡,探讨氟桂利嗪能否下调血肿周围Fas的表达而减轻神经细胞凋亡.方法 采用自体股动脉血注入大鼠尾壳核建立脑出血模型,分别于术后6h、12h、24h、2d、4d 5个时间点取脑组织,应用免疫组化方法 检测血肿周围组织Fas的表达情况,TUNEL法检测血肿周围神经细胞凋亡.结果 脑出血组大鼠脑血肿周围组织Fas的表达及细胞凋亡明显高于其他组(P＜0.01),氟桂利嗪治疗组上述指标均低于脑出血组(P＜0.01),而高于假手术组(P＜0.01), Fas的表达与血肿周围神经细胞的凋亡呈正相关(r=0.953,P <0.05).结论 Fas、神经细胞凋亡参与了大鼠脑血肿周围脑组织损伤的病理生理过程;氟桂利嗪能抑制血肿周围Fas的表达,减轻神经细胞凋亡.
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| 关 键 词： | 脑出血 Fas 细胞凋亡 氟桂利嗪 |
The relation between the expression of Fas and neuron apoptosis in perifocal tissue of intracerebral hemorrhage in rats and the effects of Flunarizine |
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| Li Jianshe,Bai Hongying,Wang Jinlan,et al.. The relation between the expression of Fas and neuron apoptosis in perifocal tissue of intracerebral hemorrhage in rats and the effects of Flunarizine[J]. Chinese Journal of Practical Neruous Diseases, 2009, 12(3) |
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| Authors: | Li Jianshe Bai Hongying Wang Jinlan et al. |
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| Affiliation: | Li Jianshe,Bai Hongying,Wang Jinlan,et al.Department of Neurology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China |
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| Abstract: | Objective To observe the expression of Fas in perifocal tissue of intracerebral hemorrhage(ICH)and the relation between Fas and neuron apoptosis in perifocal tissue of ICH,invest whether Flunarizine can decrease the expression of Fas and then inhibit neuron apoptosis.Methods ICH models were induced in rats with injection of autologous blood into the right caudat.Each group was divided into 5 various stages:6h,12h,24h,2d,4d,protein expression of Fas in the perihematomal areas was detected by immunohistchemis... |
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| Keywords: | Fas |
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