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| 组织型纤溶酶原激活物及其抑制物与静脉血栓栓塞症的关系 | |
| 引用本文： | 马涵英,赵铁夫,温绍君,张维君,周玉杰.组织型纤溶酶原激活物及其抑制物与静脉血栓栓塞症的关系[J].新乡医学院学报,2011,28(6):728-730. |
| 作者姓名： | 马涵英 赵铁夫 温绍君 张维君 周玉杰 |
| 作者单位： | 1. 首都医科大学附属北京安贞医院十二病房,北京,100029 2. 首都医科大学附属北京安贞医院十一病房,北京00029 3. 北京市心肺血管疾病研究所高血压研究室,北京,100029 |
| 基金项目： | 国家重点科技攻关计划，首都医学发展科研基金 |
| 摘 要： | 目的探讨组织型纤溶酶原激活物(t-PA)及其抑制物-1(PAI-1)血浆水平与静脉血栓栓塞症的关系。方法 87例肺动脉血栓栓塞(PTE)患者,根据是否合并深静脉血栓形成(DVT)分为2组:合并DVT患者52例,未合并DVT患者35例,同期入选性别、年龄匹配对照者80例。酶联免疫吸附试验测定血浆PAI-1和t-PA水平,聚合酶链反应-限制性片段长度多态性法检测PAI-1基因型。结果未合并DVT组t-PA明显降低,PAI-1明显升高,与合并DVT组、对照组比较差别有统计学意义(P<0.05),而合并DVT组与对照组比较差别无统计学意义(P>0.05)。在3组中,无论何种基因型,未合并DVT组的PAI-1血浆水平均最高。在4G/4G基因型和4G/5G基因型中,未合并DVT组与对照组和合并DVT组比较差别均有统计学意义(P<0.05)。结论未合并DVT的PTE患者存在明显的低纤溶状态。 |
| 关 键 词： | 深静脉血栓形成 肺动脉血栓栓塞 纤溶酶原激活物 纤溶酶原激活物抑制物-1 |
Role of tissue plasminogen activator and its inhibitor in vein thromboembolism |
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| MA Han-ying,ZHAO Tie-fu,WEN Shao-jun,ZHANG Wei-jun,ZHOU Yu-jie.Role of tissue plasminogen activator and its inhibitor in vein thromboembolism[J].Journal of Xinxiang Medical College,2011,28(6):728-730. | |
| Authors: | MA Han-ying ZHAO Tie-fu WEN Shao-jun ZHANG Wei-jun ZHOU Yu-jie |
| Institution: | MA Han-ying1,ZHAO Tie-fu2,WEN Shao-jun3,ZHANG Wei-jun1,ZHOU Yu-jie1(1.the 12th Department,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China,2.the 11th Department,3.Hypertension Research Department,Beijing Insistitute of Heart Lung and Vessel Disease,China) |
| Abstract: | Objective To investigate the role of tissue plasminogen activator(t-PA) and its inhibitor plasminogen activator inhibitor-1(PAI-1) in vein thromboembolism patients.Methods According to accompany with deep vein thrombosis(DVT),eighty-seven patients with pulmonary thromboembolism(PTE) were devided into two groups.Fifty two patients in with DVT group and thirty-five patients in without DVT group.Eithty healthy person were enrolled as control group.Plasma PAI-1 and t-PA levels were measured by enzyme linked imm... |
| Keywords: | deep vein thrombosis pulmonary thromboembolism tissue plasminogen activator plasinogen activator inhibitor-1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |